There is nothing more "creepy" than a David Cronenberg movie.
Ralph Fiennes transforms into a spider through a tunnel of psychosis. This to me, was much more effective than Jeff Goldblum's metamorphosis into a fly.
I like Cronenberg when he's pyschologically strange. Take "Dead Ringers" for instance. Fiennes is on par with Jeremy Irons' performance.
And Miranda Richardson in a dual role, looks like she's having a hell of a lot of fun as a strumpet.
Spider's deluge of thoughts when he's released from a mental hospital and trying to put together the pieces of his existence reminds me of "Memento." Something horrible has happened in the past and he's piecing together fragments of memory just like Guy Pearce.